Oral Interferon

Monday, October 06, 2014 12:21 PM

Intron A, recombinant interferon Alfa-2b, is used orally for the treatment of conditions ranging from feline herpes virus (FHV-1) to papilloma virus in canines. Although dosing guidelines are present in common veterinary literature for the treatment of FHV, there is currently an ongoing trial and error present for virtually every other condition it is used to treat.


Current recommended dosing for chronic FHV is 30 units once daily. This is a seven day on and seven day off rotating therapy. In the treatment of canine papilloma virus the recommended dose in Plumb’s Veterinary Drug Handbook, is 1.5-2 million units subcutaneously three times weekly. The above literature also presents oral dosing at 1000 units per day for papilloma, pododermatitis, and keratomas. At Roadrunner Pharmacy we have seen veterinarians in the United States empirically using doses up to 20,000 units once daily for various conditions in canines, including papilloma virus.


The primary difficulty in providing interferon to pet owners has been the availability of convenient oral dosage forms. Prior to development of an oral solution stable at refrigerated temperatures many veterinarians would freeze aliquots in individual syringes. These products have been referred to as “Interferon Popsicles.” These would be sent home with pet owners, thawed, and then administered once daily. Currently Roadrunner Pharmacy, at your request, can compound a solution up to 100,000 units/ml. When shipped on ice and refrigerated upon arrival our formulation has an independently verified shelf life of 90 days!